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Warwick Chemicals
Warwick Chemicals provide the power within many of the world's washing powder and cleaning products. The company lead the global market in the manufacture and supply of bleach activators for the detergent and biocides industries. Each year, Warwick's products enable over two billion consumers around the world to wash their clothes at lower temperatures without sacrificing cleaning performance. For over 30 years, Warwick Chemicals has manufactured Mykon grades of TAED, an activator which produces the powerful oxygen based bleach, per acetic acid.
Warwickchem.com ~
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Gulf Coast Adhesives - 3M Scotch-Weld (formerly Rite-Lok) and ND Industries quality adhesive products at discount prices for industry and manufacturing
Gulf Coast Adhesives is an ISO 9001 certified specialty chemical manufacturer and supplier specializing in industrial adhesives, 3M Scotch-Weld (formerly Rite Lok), sealants, nd epoxies - including specialized coating epoxies, Roofing Epoxy Coatings, Flooring Epoxy Coatings, 1-part epoxies, 2-part epoxies, High Temperature Epoxies, Potting Compounds, Ethyl Cyanoacrylates, Methyl Cyanoacrylates, High Temperature Cyanoacrylates, Flexible Cyanoacrylates, Rubber Toughened Cyanoacrylates, Low Odor Cyanoacrylates, Surface Insensitive, Plastic & Rubber Cyanoacrylates, Threadlockers, Retaining Compounds, Hydraulic and Pipe Sealants, Gasket Makers, Cyanoacrylate Accelerators, Anaerobic Primers, Structural Adhesive Activators, UV Curing Compounds, Surface Mount Adhesives, Vacuum Impregnation Sealants, Debonders and Cleaners. Hydra Fast-En DC12929, Resistol-5000
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SMBiochemicals-QVD-OPH-Z-VAD-FMK- Z-DEVD-FMK-Caspase inhibitor and substrates
Q-VD-OPH, A new generation broad spectrum Caspase Inhibitor
QVDOPH is a non- FMK new generation broad spectrum inhibitor that offers improvement in potency, stability and toxicity over the bench mark caspase inhibitor Z-VAD-FMK. Q-VD-OPH doesn’t cross reacts with cathepsins or calpains and FMK (Fluoromethyl Ketones) does.
The improvements derive from significant changes that include replacement of the carbobenzoyloxy blocking group (Z) with a Quinoline derivative (Q), modification of the tripeptide sequence from VAD to VD, and replacement of fluoromethyl ketone (FMK) with the non toxic 2,6-difluorophenoxy methyl (OPH) group.
The mechanism of action involves the formation of an irreversible thioether bond between the aspartic acid derivative in the inhibitor and the active site cysteine with displacement of 2,6-difluorphenoxy group.
Q-VD-OPH is a small hydrophobic compound . Therefore, DMSO is required for solubilization. Stock solutions as high as 200 mg / ml have been prepared in DMSO.
To retain solubility in water at concentrations above 1 mg / ml, 80 % DMSO is suggested.
Q-VD-OPH is effective in vitro at concentrations of 10uM to 20uM. For tissue culture studies 10mM or 20mM stock solutions are prepared in DMSO and diluted 1:1000 directly into the tissue culture medium.
For studies in vivo Q-VD-OPH has been administered in 80% to 100% DMSO to assure solubility at the doses given. A dose of 20mg/Kg has been used most frequently.
Q-VD-OPH has been shown to inhibit recombinant Caspases 2, 3, 8 and 9 with IC50 values ranging from 25 to 400 nM.
A preliminary acute toxicity screen was done in which mice were injected IP with 200 mg/kg, 500 mg/kg or 1000 mg /kg in 100 % DMSO. Mice were sacrificed and autopsied 24 hours later. No gross pathologies were seen and no evidence of toxicity was observed in histological sections from major organs.
Q-VD-OPH, A new generation broad spectrum Caspase Inhibitor
Q-VD-OPH is a non- FMK new generation broad spectrum inhibitor that offers improvement in potency, stability and toxicity over the bench mark caspase inhibitor Z-VAD-FMK. Q-VD-OPH doesn’t cross reacts with cathepsins or calpains and FMK (Fluoromethyl Ketones) does.
The improvements derive from significant changes that include replacement of the carbobenzoyloxy blocking group (Z) with a Quinoline derivative (Q), modification of the tripeptide sequence from VAD to VD, and replacement of fluoromethyl ketone (FMK) with the non toxic 2,6-difluorophenoxy methyl (OPH) group.
The mechanism of action involves the formation of an irreversible thioether bond between the aspartic acid derivative in the inhibitor and the active site cysteine with displacement of 2,6-difluorphenoxy group.
Q-VD-OPH is a small hydrophobic compound . Therefore, DMSO is required for solubilization. Stock solutions as high as 200 mg / ml have been prepared in DMSO.
To retain solubility in water at concentrations above 1 mg / ml, 80 % DMSO is suggested.
Q-VD-OPH is effective in vitro at concentrations of 10uM to 20uM. For tissue culture studies 10mM or 20mM stock solutions are prepared in DMSO and diluted 1:1000 directly into the tissue culture medium.
For studies in vivo Q-VD-OPH has been administered in 80% to 100% DMSO to assure solubility at the doses given. A dose of 20mg/Kg has been used most frequently.
Q-VD-OPH has been shown to inhibit recombinant Caspases 2, 3, 8 and 9 with IC50 values ranging from 25 to 400 nM.
Smbiochemicals.com ~
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Agrofill - Fertilizers, Biological Fertilizers, Foliar Fertilizer, Fertigation
Agrofill is an Italian Company specialized in fertilizers production and distribution. Agrofill is a biological fertilizers producer, agriculture fertilizers producer. The production comprehends foliar fertilizers in powder, liquid fertilizers, foliar fertilizers in soluble powder, simple liquid fertilizers, compound liquid fertilizers, soluble fertirrigation fertilizers, foliar fertilizers, garden fertilizers, gardening fertilizers and fertilizers for gardening, fertilizers for lawns, hydroponic fertilizers - fertilizers for hydroponic systems. Agrofill production also comprehends liquid organic fertilizers, organic fertilizers in powder and organic fertilizers in soluble powder, simple fertilizers, compound fertilizers, granular fertilizers, fertilizers in pellets, pellet fertilizers or pelletized fertilizers. Agrofill also is an Italian producer of specific fertilizers and special fertilizers such as: fertilizers based on microelements, fertilizers based on secondary elements, fertilizers based on sea-weed, biological fertilizers, fertilizers for localized applications, organic fertilizers.
Agrofill.com ~
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